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探讨大肠癌的发病机制,寻求切实可行的早期诊断方法,有利于早发现、早治疗,提高患者生存率与生存质量,对改善其预后亦具有重大的理论和实际意义。研究表明RUNX3发现晚、其研究相对较少,p53基因是迄今发现与人类肿瘤相关性最高的基因[1]。本研究采取免疫组织化学SP法检测RUNX3和p53蛋白在大肠癌组织中的表达特点,以探讨二者在大肠癌发生和发展中的不同作用及其病理学相互关系。
Exploring the pathogenesis of colorectal cancer and seeking for feasible early diagnosis methods are beneficial to early detection and early treatment and improve the survival rate and quality of life of patients with great theoretical and practical significance to improve their prognosis. Studies have shown that RUNX3 found late, its relatively small research, p53 gene is by far found the most relevant genes in human tumors [1]. In this study, immunohistochemical SP method was used to detect the expression of RUNX3 and p53 protein in colorectal cancer tissues to explore the different roles of both in the occurrence and development of colorectal cancer and its pathological correlation.