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茄科植物曾因其抗胆碱能性质而被作为抗哮喘药物使用。然而自20世纪以来,大量研究逐渐证实烟草烟雾暴露是多种疾病的危险因素。烟草烟雾暴露可导致支气管哮喘患者症状控制不佳,增加急性发作风险和加速肺功能下降等。其机制可能有改变支气管哮喘气道炎症表型、加重气道重塑和气道高反应性,并引起气道对糖皮质激素治疗不敏感。目前对烟雾暴露支气管哮喘患者的治疗管理主要包括控烟以及其他药物干预,如吸入糖皮质激素、长效β受体激动剂、白三烯受体拮抗剂和他汀类药物等。
Solanaceous plants have been used as anti-asthma drugs because of their anticholinergic properties. However, since the 20th century, a large number of studies have gradually confirmed that tobacco smoke exposure is a risk factor for various diseases. Tobacco smoke exposure can lead to poor symptom control in patients with bronchial asthma, increased risk of acute attacks and accelerated lung function decline. Its mechanism may change the airway inflammation bronchial asthma phenotype, aggravate airway remodeling and airway hyperresponsiveness, and cause airway glucocorticoid treatment is not sensitive. At present, the management and management of smoke exposure bronchial asthma patients mainly include tobacco control and other drug interventions such as inhaled corticosteroids, long-acting β-agonists, leukotriene receptor antagonists and statins.