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目的:研究黄杞总黄酮对大鼠实验性脑缺血的保护作用。方法:取Wistar大鼠,随机分为假手术组、模型组、黄杞总黄酮组(500,250,125 mg.kg-1)和三七通舒胶囊(50 mg.kg-1)组,采用线栓法和结扎双侧颈总动脉法复制大鼠脑缺血模型,观察黄杞总黄酮对局灶性脑缺血大鼠神经功能症状、脑梗死面积,对急性脑缺血再灌注损伤大鼠脑含水量以及脑组织SOD活性、MDA和NO水平的影响。结果:黄杞总黄酮对局灶性脑缺血大鼠的神经运动障碍有明显改善作用,也明显减小脑梗死面积;同时能减轻急性脑缺血再灌注损伤引起的大鼠脑水肿,提高损伤脑组织的SOD活性,降低MAO以及NO水平。结论:黄杞总黄酮对大鼠实验性脑缺血有一定的保护作用。
Objective: To study the protective effect of flavonoids from Radix et Rhizoma Rhei on experimental cerebral ischemia in rats. Methods: Wistar rats were randomly divided into sham operation group, model group, total flavonoids of Huangqi group (500, 250, 125 mg.kg-1) and Sanqi Tongshu capsule (50 mg.kg-1) And bilateral ligation of common carotid artery occlusion rat model of cerebral ischemia was observed Huangqi total flavonoids on focal cerebral ischemia in rats with neurological symptoms, cerebral infarction area, acute cerebral ischemia-reperfusion injury in rat brain Water content and brain SOD activity, MDA and NO levels. Results: Total flavonoids from Radix et Rhizoma Rhei could obviously improve the neurological dyskinesia in rats with focal cerebral ischemia and also significantly reduce the infarct size. At the same time, it can reduce the cerebral edema in rats induced by acute cerebral ischemia-reperfusion injury and improve Injury brain SOD activity, reduce MAO and NO levels. Conclusion: Flavonoids from Huangqi can protect rats from experimental cerebral ischemia.