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目的 探讨中药尿毒清冲剂与西医结合治疗早、中期慢性肾功能衰竭 (CRF)对改善肾功能和延缓肾功能衰竭进展的疗效。方法 将 78例早、中期CRF患者随机分成两组。对照组 3 0例仅予西医治疗 ,包括饮食疗法 (优质低蛋白、低磷、高糖饮食 ) ,纠正水、电解质和酸碱平衡失调 ,合并高血压者给予降压药物 ,合并感染者使用抗生素治疗等 ;治疗组 48例在上述西医治疗的基础上服用尿毒清冲剂 2 5～ 40g/d。疗程均为 2个月。观察其临床疗效、副作用及对CRF患者转归的影响。结果 ①治疗组总有效率为 73 % ,显效率 40 % ,明显高于对照组的 47%和 7% (P <0 .0 1) ;②治疗组治疗后Scr和BUN均显著降低 (P <0 .0 1) ,对照组仅BUN显著降低 (P <0 .0 5 ) ,Scr无明显降低 (P >0 .0 5 ) ;③ 1a内治疗组中有2 /8的患者进入终末期 (ESRD) ,显著低于对照组的 7/10 ,P <0 .0 1;④两组均未见明显毒副作用。结论 中西医结合治疗早、中期CRF患者 ,能显著提高治疗CRF的有效率 ,降低Scr,改善肾功能 ,降低ESRD的发生率 ,延缓肾功能衰竭进展。
Objective To investigate the curative effect of combining traditional Chinese medicine and Niaoduqing granule with western medicine in treating early and intermediate chronic renal failure (CRF) on improving renal function and retarding the progression of renal failure. Methods 78 patients with early and intermediate CRF were randomly divided into two groups. The control group of 30 cases only treated with Western medicine, including diet (high-quality low-protein, low-phosphorus, high-sugar diet), correct water, electrolyte and acid-base balance disorders, hypertension were given antihypertensive drugs, Etc .; the treatment group of 48 patients on the basis of the above Western medicine on the use of nourishing agent 12 ~ 40g / d. Treatment are 2 months. To observe the clinical efficacy, side effects and outcome of CRF patients. Results ① The total effective rate was 73% in the treatment group and the effective rate was 40%, which was significantly higher than 47% and 7% in the control group (P <0.01). ② The Scr and BUN in the treatment group were significantly decreased (P < (P <0.05), while the level of Scr had no significant difference (P> 0.05); ② Two-eighths of patients in the 1a-treated group entered the final stage ESRD) was significantly lower than that of the control group (7/10, P <0.01). ④ No obvious side effects were observed in both groups. Conclusion Integrative treatment of early and intermediate CRF patients can significantly improve the effective rate of treatment of CRF, reduce Scr, improve renal function, reduce the incidence of ESRD, delay the progress of renal failure.