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将难溶性药物分散于水溶性的高分子载体中,使药物结晶性降低或消失而溶解性增强,可提高其生物利用度。作者曾用结晶乳糖作为硝苯啶(NP)细粒的被膜,用聚乙烯吡咯烷酮(PVP)作为载体制成固体分散剂,使NP的溶解性和生物利用度得到改善。但是,由于NP-PVP的固体分散系对湿气不稳定,经过一段时间可引起非品质NP的结晶化而导致溶解性和生物利用度降低。为此,作者又改用羟丙基甲基纤维素(HPMC)为载体,
The poorly soluble drug dispersed in the water-soluble polymer carrier, the drug crystallinity decreased or disappeared and increased solubility, can improve its bioavailability. The authors used crystalline lactose as a coating of nifedipine (NP) fine particles and made a solid dispersant using polyvinylpyrrolidone (PVP) as a carrier to improve the solubility and bioavailability of NP. However, since the solid dispersion of NP-PVP is not stable to moisture, crystallinity of non-quality NPs may be caused for a period of time to result in decreased solubility and bioavailability. To this end, the author changed to hydroxypropyl methyl cellulose (HPMC) as a carrier,