1835年Cruveilhier最先报告了多发性硬化的病理。1868年Charcot等报告了临床。中枢神经出现多数脱髓鞘病灶引起相应临床症状,原病灶可修复,症状缓解,但又可出现新病灶和新症状,这是多发性硬化的病程特点,多数可生存20年以上。老病灶有大量胶质纤维,这种胶质增生使病灶局部瘢痕化,其切面触之较正常脑组织硬。从病理角度,把这些多数较硬 1835 Cruveilhier first reported the pathology of multiple sclerosis. Charcot et al. 1868 reported clinical. The majority of central nervous demyelinating lesions caused by the corresponding clinical symptoms, the original lesions can be repaired, the symptoms ease, but there may be new lesions and new symptoms, which is the characteristics of the course of multiple sclerosis, the majority of survival over 20 years. Old lesions have a large number of glial fibers, the glial hyperplasia of the lesion local scarring, the touch of its section than the normal brain tissue hard. From the pathological point of view, put these most hard