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目的探讨儿童急性呼吸道感染血清免疫球蛋白M(Ig M)测定与分析。方法 240例急性呼吸道感染患儿,以酶联免疫吸附测定ELISA方式对患儿血清中Ig M抗体进行检测,并以患儿年龄、性别等为依据相应的统计分析。结果急性呼吸道感染病原体阳性检出率和患儿性别差异无统计学意义(P>0.05);而不同年龄组比较其肺炎支原体(Mp)、肺炎衣原体(Cpn)、呼吸道合胞病毒(RSV)指标差异有统计学意义(P<0.05),其中年龄<3岁的儿童其阳性率为31.3%,以RSV检出为主,其次为Mp;年龄>3岁的儿童其阳性率为44.8%,以Mp为主,其次为Cpn。结论血清中特异性Ig M抗体监测可作为急性期感染的一项重要指标,其可为临床诊疗及合理用药提供有效的依据。
Objective To investigate the determination and analysis of serum immunoglobulin M (IgM) in children with acute respiratory infection. Methods A total of 240 children with acute respiratory infection were enrolled in this study. Serum IgM antibody was detected by enzyme-linked immunosorbent assay (ELISA). The corresponding statistical analysis was based on the age and gender of the children. Results There was no significant difference in the positive rate of pathogens of acute respiratory infection and the gender of children (P> 0.05). However, in different age groups, the positive rate of Mp, Cpn, RSV The difference was statistically significant (P <0.05). The positive rate was 31.3% in children younger than 3 years old, mainly in RSV, followed by Mp. The positive rate was 44.8% in children aged> 3 years Mp dominated, followed by Cpn. Conclusion Serum specific IgM antibody monitoring can be used as an important indicator of acute infection, which can provide an effective basis for clinical diagnosis and treatment.