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目的探讨前列地尔对糖尿病肾病患者疗效观察及对微炎症状态、血液流变学水平的影响。方法将河南科技大学第三附属医院收治并确诊的108例糖尿病肾病患者随机分为两组。对照组54例采用降糖、低蛋白饮食、运动等常规内科治疗,而试验组54例在对照组基础上加用前列地尔治疗。比较两组患者临床疗效及微炎症状态、血液流变学的差异。结果治疗后试验组患者血尿素氮、血肌酐及24h尿微白蛋白排泄率显著降低,其也显著低于同期对照组,比较有统计学差异(P<0.05);治疗后试验组患者IL-6、CRP、全血高切黏度及血浆黏度显著降低,其也显著低于同期对照组(P<0.0 5)。结论前列地尔治疗糖尿病肾病患者临床效果显著,其能够有效保护患者肾功能,降低微炎症因子水平,改善血液流变学,值得临床选择。
Objective To investigate the curative effect of alprostadil on diabetic nephropathy and its effect on micro-inflammation and hemorheology. Methods 108 cases of diabetic nephropathy admitted and diagnosed in the Third Affiliated Hospital of Henan University of Science and Technology were randomly divided into two groups. In the control group, 54 cases were treated by conventional medicine such as hypoglycemic, low-protein diet and exercise, while 54 cases in the experimental group were treated with alprostadil on the basis of the control group. The clinical efficacy, micro-inflammatory status and hemorheology were compared between the two groups. Results After treatment, the blood urea nitrogen, serum creatinine and urinary albumin excretion rate in the experimental group were significantly lower than those in the control group (P <0.05). After treatment, the levels of IL- 6, CRP, whole blood viscosity and plasma viscosity were significantly lower, which was significantly lower than the control group (P <0.0 5). Conclusion Alprostadil treatment of patients with diabetic nephropathy significant clinical effect, which can effectively protect patients with renal function, reduce the level of micro-inflammatory factors, improve blood rheology, deserved clinical choice.