The dynamic scaling properties of growing surfaces with growth inhomogeneities are studied by applying a dynamic renormalization-group analysis to the generalized Kardar-Parisi-Zhang(hereafter abbreviated to KPZ) equation,which contains an additional term of growth inhomogeneities. In a practical crystal growth process, these growth inhomogeneities can be induced by surface impurities and defects and are modeled by a screened Coulomb function in this paper. Our results show that the existence of the growth inhomogeneities can significantly change the dynamic scaling properties of a growing surface and can lead to a rougher surface.