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目的:探讨平阳霉素/博来霉素联合顺铂(BP方案)、5-氟尿嘧啶+异环磷酰胺联合顺铂(FIP方案)在宫颈癌新辅助化疗(Neoadjuvant Chemotherapy,NACT)的疗效及临床意义。方法:2004~2008年我院收治的Ib2-IIb期巨块型宫颈癌共62例,其中36例行BP或FIP方案化疗1~2个疗程后行根治性手术,为研究组;另26例直接行根治性手术,为对照组;术前评价NACT的疗效,并比较两组术中出血量、术后病理特征及并发症。结果:研究组36例患者术前进行NACT有效率为86%;术后病理检查示淋巴结阳性率,阴道切缘阳性率及宫旁累及率均较对照组低,差异有显著性。结论:利用BP,FIP方案对宫颈癌患者进行新辅助化疗有效、安全、经济,可缩小癌肿体积,增加手术切除率。
Objective: To investigate the efficacy and clinical efficacy of bleomycin plus bleomycin combined with cisplatin (BP) and 5-fluorouracil plus ifosfamide plus cisplatin (FIP) in cervical cancer with neoadjuvant chemotherapy (NACT) significance. Methods: A total of 62 Ib2-IIb massive cervical cancers were treated in our hospital from 2004 to 2008. Among them, 36 patients underwent radical surgery after 1 or 2 courses of chemotherapy with BP or FIP regimen, and the other 26 patients The curative effect of NACT was evaluated preoperatively, and the blood loss, postoperative pathological features and complications were compared between the two groups. Results: 36 patients in study group had 86% of NACT preoperatively. The postoperative pathological examination showed that the positive rate of lymph nodes, the positive rate of vaginal margins and the paracancerous involvement rate were lower than those of the control group. The difference was significant. Conclusion: The neoadjuvant chemotherapy for cervical cancer patients with BP and FIP regimens is effective, safe and economical, which can reduce the volume of cancer and increase the rate of resection.