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目的探讨视网膜血管异常与缺血性脑卒中的关系。方法采用限定人群整群抽样法抽取武汉市洪山区的2个社区作为本研究的基线人群。基线调查包括问卷调查和全面的眼科检查,评估视网膜眼底血管直径,随访调查包括问卷调查、眼科检查和头颅MRI扫描,评估脑白质损害和腔隙性脑梗死的严重程度和发生率。结果视网膜血管直径同白质损害的严重程度及腔隙性脑梗死的发生率有关,其中以视网膜小静脉直径更具价值。视网膜小静脉直径每增加1个标准差(1SD),室周白质损害进展1.6倍,皮质下白质损害进展2.0倍,腔隙性脑梗死的发生率上升1.64倍。结论视网膜血管异常与MRI定义的亚临床脑梗死之间具有相关性。视网膜血管异常可作为评价脑卒中发生、发展的危险性的独立评估指标之一,其中以视网膜小静脉直径更具价值。
Objective To investigate the relationship between retinal vascular abnormalities and ischemic stroke. Methods A limited population cluster sampling method was used to extract 2 communities in Hongshan District of Wuhan City as the baseline population of this study. Baseline surveys included questionnaires and comprehensive eye examinations to assess retinal vascular diameter. Follow-up surveys included questionnaires, eye exams and cranial MRI scans to assess the severity and incidence of white matter damage and lacunar infarctions. Results The diameter of retinal vessels was related to the severity of white matter damage and the incidence of lacunar infarcts, of which the diameter of the small retinal vein was more valuable. The retinal vein venous diameter increased by 1 standard deviation (1SD), ventricular white matter damage progress 1.6 times, subcortical white matter damage 2.0 times, the incidence of lacunar infarction increased 1.64 times. Conclusions There is a correlation between retinal vascular abnormalities and MRI-defined subclinical cerebral infarction. Retinal vascular abnormalities can be used as an independent evaluation index to evaluate the risk of stroke and development, in which the diameter of the small retinal vein is more valuable.