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目的：探讨PDCA循环在医院危险化学品管理中的应用及其效果，旨在进一步提高有害物质的管理工作，保障患者安全。方法分析危险化学品管理不规范原因，并采用PDCA循环进行规范管理，包括制定持续改进计划(P)，根据计划展开阶段的项目实施(D)，进行质量指标监测(C)，进而持续改进措施(A)。结果经过跨部门协作及各项改进措施的实施，119个科室巡查结果显示，2015年2月危险化学品规范管理的执行率整体上升，3月的执行率为80%～90%，4月后达到95%以上。结论 PDCA循环应用于医院危险化学品管理有效提升了危险化学品规范管理的执行率，保障了危险化学品的规范使用，保障了患者安全，对于规范管理医院的其他有害物质具有一定的借鉴意义。“,”ObjectiveThe paper discusses the application of PDCA cycle in dangerous chemicals management in the hospital and its effect to further improve the management of hazardous substances and guarantee patient safety.MethodThe cause of non-standard dangerous chemicals management is analyzed. PDCA cycle is used for standard management, including development of sustainable improvement plans (P), project implementation based on the development stage of the plan (D), provision of quality index monitoring (C) and sustainable improvement of the measures (A).ResultWith inter-departmental cooperation and implementation of the improvement measures, the inspection results of 119 departments show that there is a global rise in the execution rate of dangerous chemicals standard management in February, 2015. In March, the rate is 80%-90%, and it reaches to 95% or above after April. ConclusionApplication of PDCA cycle to the management of dangerous chemicals in the hospital effectively increases the execution rate of dangerous chemicals standard management, which guarantees standard use of dangerous chemicals and patient safety. It has much reference meaning to standard management of other hazardous substances in the hospital.