对口服降糖药失效的 2型糖尿病患者传统的治疗方法是采用胰岛素治疗 ,但大剂量的胰岛素应用可引起体重增加 ,而高胰岛素血症可增加糖尿病血管并发症的危险性 ,且对内源性胰岛素的分泌有抑制作用。我们用诺和灵 30 R联合二甲双胍治疗 2 1例患者观察一年 ,取得满意疗效 ,总结如下 The traditional treatment of type 2 diabetes patients with oral hypoglycemic failure is the use of insulin therapy, but high doses of insulin can cause weight gain, and hyperinsulinemia can increase the risk of diabetic vascular complications, and endogenous Inhibition of the secretion of insulin. We use Novolin 30 R combined with metformin treatment of 21 patients observed for one year, and achieved satisfactory results, summarized as follows