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目的探究人绝经期促性腺激素(HMG)和人绒毛膜促性腺激素(HCG)的联合应用对于治疗排卵障碍性不孕症的疗效。方法 75例排卵障碍性不孕患者联合应用HMG和HCG75个周期,并于月经周期第5天开始进行肌内注射HMG 75 U,选用B超、血清孕酮、雌二醇的监测数据判断排卵情况,当卵泡直径≥18 mm时,停止注射HMG,并于24 h后肌内注射HCG 5000 U,从而促进排卵。结果联合应用HMG和HCG可明显促进排卵,使排卵率高达90.8%,妊娠率可以达到总体的四分之一,卵巢过度刺激综合征(OHSS)的发生率可以达到43.2%。OHSS的发生可以明显提升多囊卵巢综合征妊娠率的发生率。结论联合应用HMG和HCG治疗排卵障碍性不孕症具有良好的效果。
Objective To investigate the efficacy of combination of human menopausal gonadotropin (HMG) and human chorionic gonadotropin (HCG) in the treatment of infertility with ovulatory dysfunction. Methods 75 cases of ovulation failure infertility patients combined with HMG and HCG 75 cycles and HMG 75 U intramuscular injection started on the 5th day of the menstrual cycle. The monitoring data of B ultrasound, serum progesterone and estradiol were used to judge the ovulation , When the follicle diameter ≥ 18 mm, stop injection of HMG, and after 24 h intramuscular injection of HCG 5000 U, thereby promoting ovulation. Results Combined application of HMG and HCG can significantly promote ovulation, the ovulation rate as high as 90.8%, the pregnancy rate can reach a quarter of the overall, ovarian hyperstimulation syndrome (OHSS) incidence can reach 43.2%. The occurrence of OHSS can significantly improve the incidence of polycystic ovary syndrome pregnancy rate. Conclusion The combination of HMG and HCG treatment of ovulatory failure of infertility with good results.