论文部分内容阅读
大鼠单次口服山豆根碱后,1小时胃肠消失给药剂量的52.5%。而肝、肺和脑组织中药量均达高峰。唯脾脏含药量在12小时达高峰。肝、脾、肾含药量较高。脑中含药量较少,可表明山豆根碱能透过血脑屏障。山豆根碱主要通过粪便排出,少部分从尿排出。口服给药后48小时粪尿药总排出累积量只占给药剂量的22.27%。其余药物是否积蓄或转化等尚待研究。
After a single oral administration of lancerate in rats, the dose of gastrointestinal disappeared one hour after administration of 52.5%. The amount of liver, lung and brain tissue reached their peak. Only spleen content reached its peak in 12 hours. Liver, spleen, kidney higher drug content. Less content in the brain, can show that the root of rhodocalcinate can penetrate the blood-brain barrier. Basidiomycosis is mainly excreted through the feces, a small part of the urine excreted. 48 hours after oral administration, the cumulative total excretion of excrement and urine drug accounted for only 22.27% of the dose. The remaining drugs whether savings or conversion remains to be studied.