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目的 :研究筛选改善高原移居青年肺通气功能的药物 ;方法 :对海拔 3 70 0m已习服的 40名士兵随机分为 4组 ,每组 1 0人 ,在上午让受试者用EGM型踏车功量机做坐位踏车运动 ,初始负荷功率 2 5W ,每 3min递增 50W ,递增至 2 2 5W踏车 3min后终止 ,计算每位受试者的肺通气量 (VEBTPS) ,然后 4组受试者分别口服酪氨酸、乙酰唑胺、依那普利加硝苯地平、安慰剂 (对照组 ) ,每天 2次 ,连服 1 5天 ,在服药 1 0天、1 5天、停药 1 0天、2 0天时重复上述运动实验 ,采用双因素方差分析 q检验 ;结果 :服药 1 0天、1 5天、停药 1 0天、2 0天时 ,酪氨酸组、乙酰唑胺组、依那普利组VEBTPS较服药前及对照组减少或明显减少 ,差别有显著性或差别有高度显著性 (P <0 .0 5或P <0 .0 1 ) ;结论 :酪氨酸、乙酰唑胺及依依那普利加硝苯地平均能提高高原移居青年的肺通气功能 ,其药物的良性作用可维持2 0天以上。
OBJECTIVE: To study the screening and screening of drugs for improving lung ventilation of young migrants from plateau. Methods: Forty soldiers who were accustomed to service at an altitude of 3 000 m were randomly divided into 4 groups (10 in each group). In the morning, The power of the car was adjusted to sitting treadmill exercise. The initial load power was 25 W, increased by 50 W every 3 minutes and then increased to 2 2 5 W treadmill 3 minutes later. The VEBTPS of each subject was calculated. Subjects were given oral tyrosine, acetazolamide, enalapril plus nifedipine, placebo (control group) twice daily for 15 days, taking 10 days, 15 days, withdrawal 1 0 days, 20 days to repeat the above exercise test, using two-factor analysis of variance q test; Results: taking 10 days, 15 days, 10 days off, 20 days, tyrosine group, acetazolamide group, The VEBTPS in enalapril group decreased or decreased significantly compared with pre-treatment and control group, and the difference was significant or significant (P <0.05 or P <0.01). Conclusion: Tyrosine, acetyl Both azole and enalapril plus nifedipine improve pulmonary ventilation in migrant young people at high altitude, and the benign effect of the drug can be maintained for 20 days .