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目的探讨肝细胞肝癌(HCC)发生、发展因素,为HCC诊治提供指导。方法应用免疫组织化学法检测60例HCC中Livin、survivin与胰岛素样生长因子-2(IGF-2)的表达,应用COX风险模型及Log-rank检验分析其与预后相关性。结果HCC中Livin、survivin的表达阳性率均高于癌旁组织及正常组织(P<0.05),且与肿瘤镜下门静脉癌栓发生密切相关(P<0.05);IGF-2表达与HCC肿瘤镜下门静脉癌栓发生、肿瘤病理分期以及肝硬化密切相关(P<0.05);相关性检验示Livin、survivin与IGF-2表达均有明显相关性,三者均为HCC的独立预后因素。结论IGF-2与Livin、survivin相互作用共同参与HCC的发展,确定其水平有助于判断HCC的预后并指导术后治疗。
Objective To investigate the occurrence and development of hepatocellular carcinoma (HCC) and provide guidance for the diagnosis and treatment of HCC. Methods The expressions of Livin, survivin and insulin-like growth factor-2 (IGF-2) were detected by immunohistochemistry in 60 cases of HCC. COX risk model and Log-rank test were used to analyze the prognosis. Results The positive rates of Livin and survivin in HCC tissues were significantly higher than those in paracancer tissues and normal tissues (P <0.05), and were closely related to tumorous portal vein thrombosis (P <0.05). The positive rates of IGF- (P <0.05). The correlation test showed that the expressions of Livin, survivin and IGF-2 were significantly correlated, all of them were independent prognostic factors of HCC. Conclusion The interaction between IGF-2 and Livin and survivin participate in the development of HCC. To determine the level of IGF-2 is helpful to judge the prognosis of HCC and guide the postoperative treatment.