以第一个扁桃酰胺类杀菌剂双炔酰菌胺为模板,在炔丙氧基的邻位引入第二个甲氧基,设计合成了15个未见文献报道的N-(3,5-二甲氧基-4-烷氧基苯乙基)扁桃酰胺类化合物(8a～8o),其结构通过核磁共振氢谱和高分辨质谱确认。初步的离体和活体杀菌试验结果表明,化合物8e、8h和8o对辣椒疫霉Phytophthora capsici具有较好的杀菌活性,其中8h和8o在62.5 mg/L下对辣椒疫霉活体抑制率达100%。 The first mandelic amide fungicide mandipropamid was used as a template to introduce a second methoxy group in the ortho-position of propargyloxy. Fifteen novel N- (3,5- Dimethoxy-4-alkoxyphenethyl) mandelic acid amide compounds (8a-8o) whose structure was confirmed by 1H nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. The preliminary in vitro and in vivo bactericidal test results showed that compounds 8e, 8h and 8o had good bactericidal activity against Phytophthora capsici, of which 8h and 8o inhibited the phytophthora capsici at 62.5 mg / L in 100% .