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目的 :探讨自发性细菌性腹膜炎 (SBP)病人腹水中粒细胞集落刺激因子 (G CSF)和C 反应蛋白 (CRP)水平的变化和临床意义。方法 :采用双抗体夹心ELISA法测定G CSF ,快速免疫消浊比浊法测定CRP。结果 :2 8例SBP病人血清和腹水G CSF和CRP水平明显高于 2 0例漏出性腹水病人 (P <0 .0 1)。SBP病人腹水中的G CSF和CRP水平明显高于血清中的水平。随着感染的控制 ,腹水中G CSF和CRP水平逐渐下降 (P <0 .0 5 )。结论 :腹水G CSF和CRP的检测有助于对SBP的诊断和疗效观察。
Objective: To investigate the changes and clinical significance of granulocyte colony stimulating factor (G CSF) and C-reactive protein (CRP) levels in ascites of patients with spontaneous bacterial peritonitis (SBP). Methods: G CSF was measured by double antibody sandwich ELISA and CRP was measured by rapid turbidity turbidimetry. Results: Serum and ascites G CSF and CRP levels in 28 patients with SBP were significantly higher than those in 20 patients with ascitic fluid leakage (P <0.01). The levels of G CSF and CRP in ascites of SBP patients were significantly higher than those in serum. With the control of infection, the level of G CSF and CRP in ascites decreased gradually (P <0.05). Conclusion: The detection of ascites G CSF and CRP is helpful to the diagnosis and curative effect of SBP.