论文部分内容阅读
急性出血坏死性胰腺炎(AHNP)大鼠随着时间延长,肺间质及肺泡水肿,肺不张,肺系数增加,且肺间质中性粒细胞浸润增多,其发病机制之一为肺微血管受损,血管通透性增强。而体内血栓素A2(TXA2)和前列环素(PGI2)比值失调,磷脂酶A2(PLA2)活性增高,脂质过氧化物(LPO)增加在此过程中起重要作用;牛磺酸能有效地降低TXB2/6-keto-PGF1α的比值,恢复其平衡,降低体内LPO水平及PLA2的活性,改善肺组织的病理形态,使肺水肿减轻,系数降低,AHNP大鼠存活时间延长,从而有助于预防AHNP并发肺损伤的发生和发展。
Acute hemorrhagic necrotizing pancreatitis (AHNP) rats with prolonged lung interstitial and alveolar edema, atelectasis, lung coefficient increased, and increased interstitial infiltration of neutrophils, one of the pathogenesis of pulmonary microvascular Impaired vascular permeability increased. However, the ratio of TXA2 and PGI2 in the body is imbalanced, the activity of PLA2 is increased, and the increase of LPO plays an important role in this process. Taurine can effectively Reduce the ratio of TXB2 / 6-keto-PGF1α, restore its balance, reduce the level of LPO in vivo and the activity of PLA2, improve the pathological morphology of lung tissue, reduce the pulmonary edema, reduce the coefficient and prolong the survival time of AHNP rats, Prevention of AHNP complicated with the occurrence and development of lung injury.