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Objective:To assess the association between X-ray repair cross-complementating group 1 (XRCC1) polymorphisms and pancreatic cancer.Methods:We searched MEDLINE,Web of Science and HuGE Navigator at June 2010,and then quantitatively summarized associations of the XRCC1 polymorphisms with pancreatic cancer risk using meta-analysis.Results:Four studies with 1343 cases and 2302 controls were included.Our analysis found:at codon 194,the Trp allele did not decrease pancreatic cancer risk (Arg/Arg versus Trp/Trp:OR=0.97;95% CI:0.48-1.96;P=0.97;Arg/Arg versus Arg/Trp:OR=0.89;95% CI:0.70-1.13;P=0.55;Arg/Trp versus Trp/Trp:OR=1.06;95% CI:0.52-2.16;P=0.90);at codon 280,only a study showed a nonsignificant association between single nucleotide polymorphism with pancreatic cancer risk;at codon 399,the Gln allele also showed no signi?cant effect on pancreatic cancer compared to Arg allele (Arg/Arg versus Gln/Gln:OR=0.94;95% CI:0.74-1.18;Arg/Arg versus Arg/Gln:OR=0.97;95% CI:0.83-1.13;Arg/Gln versus Gln/Gln:OR=0.97;95% CI:0.77-1.22).The shape of the funnel plot and the Egger’s test did not detect any publication bias.Conclusion:There is no evidence that XRCC1 polymorphisms (Arg194Trp,Arg280His,and Arg399Gln) are associated with pancreatic cancer risk.
Objective: To assess the association between X-ray repair cross-complementating group 1 (XRCC1) polymorphisms and pancreatic cancer. Methods: We searched MEDLINE, Web of Science and HuGE Navigator at June 2010, and then quantitatively began associations of the XRCC1 polymorphisms with Results: Four studies with 1343 cases and 2302 controls were included. Our analysis found: at codon 194, the Trp allele did not reduce pancreatic cancer risk (Arg / Arg versus Trp / Trp: OR = 0.97 ; 95% CI: 0.48-1.96; P = 0.97; Arg / Arg versus Arg / Trp: OR = 0.89; 95% CI: 0.70-1.13; P = 0.55; Arg / Trp versus Trp / Trp: OR = 1.06; 95 % Cod: 0.52-2.16; P = 0.90); at codon 280, only a study showed a nonsignificant association between single nucleotide polymorphism with pancreatic cancer risk; at codon 399, the Gln allele also showed no signi? Cant effect on pancreatic cancer compared Arg / Arg versus Arg / Gln: OR = 0.97; 95% CI: 0.83-1.13; Arg / Gln versus Glg 95% CI: 0.77-1.22). The shape of the funnel plot and the Egger’s test did not detect any publication bias. Confc: There is no evidence that XRCC1 polymorphisms (Arg194Trp, Arg280His, and Arg399Gln ) are associated with pancreatic cancer risk.