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目的 :对 5 9例肺癌合并SVCS进行回顾性分析 ,以探讨其最佳治疗方式。方法 :本组单纯放疗 2 3例 ,单纯化疗 16例 ,综合治疗 2 0例 ,其中 6例先放疗后化疗 ,8例先化疗后放疗 ,6例放化疗同时进行 ,则总计 2 9例先行放疗 ,2 4例先行化疗。结果 :两周内开始缓解率 ,先行化疗组明显高于先行放疗组 (P <0 0 5 ) ,完全缓解率先行放疗组明显高于先行化疗组 (P <0 0 5 ) ,而总缓解率两组并无显著差异 (P <0 0 5 ) ,治疗后完全缓解组生存率明显优于未完全缓解组 (P <0 0 5 ) ,平均生存时间延长 5 5个月 ,中位生存时间延长 3 5个月。结论 :同时进行放化疗或先行 1～ 2周期冲击化疗 ,继之放疗 ,最后再酌情给予 3～ 4周期化疗。
Objective : To retrospectively analyze 59 cases of lung cancer combined with SVCS in order to discuss its best treatment. METHODS: Twenty-three patients were treated with radiotherapy alone, 16 patients were treated with chemotherapy alone, and 20 patients were treated comprehensively. Among them, 6 patients received chemotherapy after first radiotherapy, 8 patients received radiotherapy after chemotherapy, and 6 patients received radiotherapy and chemotherapy concurrently. In total, 29 patients received prior radiotherapy. Of the 24 patients receiving chemotherapy. Results: The remission rate was started within two weeks. The rate of chemotherapy was significantly higher in the prior chemotherapy group than in the prior radiotherapy group (P < 0.05). The complete remission rate was significantly higher in the first radiotherapy group than in the prior chemotherapy group (P <0 05). There was no significant difference between the two groups (P <0 05). The survival rate in the complete remission group after treatment was significantly better than that in the incomplete remission group (P <0 05). The average survival time was extended by 5 5 months, and the median survival time was prolonged. 3 5 months. Conclusions: Simultaneous chemoradiation or first-to-two-cycle impact chemotherapy followed by radiotherapy, followed by 3 to 4 cycles of chemotherapy as appropriate.