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芒果苷属双苯吡酮类化合物,是芒果叶的主要活性成分,具有抗炎作用[3]。炎症是缺血/再灌注(I/R)损伤发生的重要机制[1-2],但是芒果苷对肝脏I/R损伤的保护作用尚未见报道。本研究观察了芒果苷对I/R大鼠肝脏炎症反应以及损伤的影响。1材料与方法1.1仪器生化自动分析仪(购自德国Bayer公司),实时定量PCR仪(购自美国Thermo公司)。1.2方法1.2.1实验分组将SD大鼠(由河北大学实验动物中心提供)随机分为假手术组、I/R组、芒果苷预处理组、芒果苷-
Mangiferin is a diphenyopyrazone compound, is the main active ingredient of mango leaves, has an anti-inflammatory effect [3]. Inflammation is an important mechanism of ischemia / reperfusion (I / R) injury [1-2]. However, the protective effect of mangiferin on liver I / R injury has not been reported yet. In this study, we observed the effect of mangiferin on hepatic inflammatory response and injury in I / R rats. 1 Materials and Methods 1.1 Instrument Biochemical Analyzer (purchased from Bayer, Germany), real-time PCR instrument (purchased from the United States Thermo Corporation). 1.2 Methods 1.2.1 Experimental group SD rats (provided by the Experimental Animal Center of Hebei University) were randomly divided into sham operation group, I / R group, mangiferin pretreatment group, mangiferin -