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目的:探讨急性冠脉综合征(ACS)患者单核细胞中过氧化物酶体增殖激活受体δ(PPARδ)的表达水平与血清IL-6和IL-10水平的相关性。方法:分离55例ACS患者和47例健康对照者的外周血单核细胞,应用RT-PCR法检测PPARδ的表达;应用ELISA法检测白血清IL-6和IL-10的水平。结果:ACS患者外周血单核细胞中PPARδ的表达水平显著低于健康对照组(P<0.01);血清IL-6水平显著高于健康对照组(P<0.01);而血清IL-10的水平显著低于健康对照组(P<0.01)。PPARδ的表达水平与血清IL-6的水平呈负相关(r=-0.413,P<0.05),与血清IL-10的水平呈正相关(r=0.601,P<0.05)。结论:PPARδ可能在ACS的发病中具有重要作用。
Objective: To investigate the correlation between the expression of peroxisome proliferator - activated receptor δ (PPARδ) and the level of IL - 6 and IL - 10 in mononuclear cells of patients with acute coronary syndrome (ACS). Methods: Peripheral blood mononuclear cells from 55 ACS patients and 47 healthy controls were isolated. The expression of PPARδ was detected by RT-PCR. The levels of IL-6 and IL-10 in serum were detected by ELISA. Results: The expression of PPARδ in peripheral blood mononuclear cells of patients with ACS was significantly lower than that of healthy controls (P <0.01), while serum IL-6 level was significantly higher than that of healthy controls (P <0.01) Significantly lower than the healthy control group (P <0.01). The level of IL-6 was negatively correlated with the level of IL-6 (r = -0.413, P <0.05), and positively correlated with the level of serum IL-10 (r = 0.601, P <0.05). Conclusion: PPARδ may play an important role in the pathogenesis of ACS.