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目的:探讨脓毒症患儿行连续肾脏替代疗法(CRRT)前应用9 g/L生理盐水液体复苏对后期肾功能及炎症因子水平的影响。方法:选取2017年2月至2019年10月期间我院收治的105例脓毒症行CRRT治疗的患儿作为研究对象，按随机平行对照法分为两组，对照组52例CRRT前给予羟乙基淀粉液体复苏，观察组53例给予9 g/L生理盐水液体复苏，比较两组患儿肾功能指标(包括血清尿素氮、肌酐及尿量等)、炎症因子水平[包括C-反应蛋白(CRP)、前降钙素原(PCT)和肿瘤坏死因子-α(TNF-α)]、急性肾损伤(AKI)发生率和生存率。结果:两组治疗后血清尿素氮、肌酐均比治疗前降低，尿量均比治疗前增加，并且观察组治疗效果明显优于对照组，两组相比差异有统计学意义(n P<0.05)。两组治疗后CRP、PCT和TNF-α均比治疗前降低，观察组明显低于对照组，两组相比差异有统计学意义(n P<0.05)。观察组AKI发生率为15.09%，生存率为71.69%，对照组AKI发生率为32.69%，生存率为48.08%，两组相比差异有统计学意义(n P<0.05)。n 结论:9 g/L生理盐水液体复苏可以改善脓毒症患儿的血流动力学，联合应用CRRT治疗可明显改善患儿的肾功能，降低炎性因子水平和AKI发生率，提高患儿的生存率，值得在临床上推广应用。“,”Objective:To investigate the effect of 9 g/L saline liquid resuscitation on renal function and inflammatory factor levels in children with continuous renal replacement thenapy(CRRT) in sepsis.Methods:A total of 105 children with sepsis undergoing CRRT who were admitted from February 2017 to October 2019 were selected as the research objects. The children were divided into two groups according to the randomized parallel control method. 52 cases of the control group were given hydroxyethyl starch liquid resuscitation before CRRT. 53 patients in the observation group were given 9 g/L saline liquid resuscitation. The renal function indexes (serum urea nitrogen, creatinine and urine output levels), inflammatory factor levels (CRP, PCT and TNF-α levels), and incidence and survival rate of acute kidney injury(AKI) were compared between the two groups.Results:After treatment, serum urea nitrogen and creatinine were lower than before treatment, and urine output was increased compared with before treatment. The treatment effect of the observation group was significantly better than that of the control group, which was statistically significant (n P<0.05). After treatment, CRP, PCT and TNF-α were lower in the two groups than before treatment, and the CRP. PCT and TNF-α in the observation group was significantly were lower than those of the control group (n P<0.05). The incidence of AKI in the observation group was 15.09%, and the survival rate of AKI was 71.69%. The incidence of AKI in the control group was 32.69%, and the survival rate of AKI was 48.08%, The incidence and mortality of AKI between the two groups were statistically significant (n P<0.05).n Conclusions:9 g/L saline fluid resuscitation can improve the hemodynamics of children, and combined with CRRT treatment, significantly improve the renal function of children, reduce the level of inflammatory factors and the incidence of AKI, and improve the survival of children rate, it is worthy of clinical application.