[目的]分析多发性骨髓瘤导致心脏损害的原因及途径。[方法]回顾性分析57例多发性骨髓瘤患者的临床资料。[结果]治疗前或治疗过程中既有或出现心脏损害16例,占28.1%;死亡25例,而直接死于心血管并发症共10例,占40%。[结论]心脏损害是多发性骨髓瘤治疗前及治疗中较常见的并发症;心脏损害是多发性骨髓瘤致死的重要原因之一。 [Objective] To analyze the causes and ways of heart damage caused by multiple myeloma. [Methods] The clinical data of 57 patients with multiple myeloma were retrospectively analyzed. [Results] There were 16 cases of cardiac damage or 28.1% before or during treatment, 25 cases died, and 10 cases died of cardiovascular complications directly, accounting for 40%. [Conclusion] Heart damage is a more common complication of multiple myeloma before and during treatment. Heart damage is one of the important causes of multiple myeloma death.