高血压、血管病、肾脏病、心血管事件时常有高尿酸血症。作者温习此关联的流行病学资料和可能的机制。一些实验研究说明尿酸并非无活性 ,它可能有益 (起抗氧化用用 )亦可能有害(刺激血管平滑肌细胞增殖和使内皮功能不正常 )。最近形成的一种轻度高尿酸血病试验模型首次提供证据 High blood pressure, vascular disease, kidney disease, cardiovascular events often have hyperuricemia. The authors review the epidemiological data and possible mechanisms of this association. Some experimental studies have shown that uric acid is not inactive, it may be beneficial (anti-oxidant use) may also be harmful (stimulate vascular smooth muscle cell proliferation and endothelial dysfunction). A recent model trial of mild hyperuricemia provides the first evidence