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目的了解2013年和2014年我院分离的鲍曼不动杆菌临床分布特征及对常用抗菌药物药敏试验结果,更好地指导临床用药。方法采用全自动微生物分析仪进行药敏试验,用WHONET软件统计和分析临床送检出的鲍曼不动杆菌资料。结果共分离出1237株鲍曼不动杆菌,检出率最高的是痰标本,病菌主要来自呼吸科重症监护室和呼吸科,其次是ICU病区。药敏结果显示鲍曼不动杆菌对多粘菌素B和美满霉素的耐药率较低,此外对其他抗生素的耐药率均很高。该菌对亚胺培南和美罗培南的耐药率83%~87%,对头孢菌素类、氨基糖苷类和氟喹诺酮类耐药率为68.5%~92.7%,对头孢噻肟和头孢曲松耐药率100%。结论医院鲍曼不动杆菌感染患者主要集中在重症监护室和呼吸科,该菌对临床常用抗菌药物已普遍耐药,应加强鲍曼不动杆菌耐药监测和抗菌药物管理。
Objective To understand the clinical distribution of Acinetobacter baumannii isolated in our hospital in 2013 and 2014 and the drug susceptibility test results of commonly used antibiotics to better guide clinical medication. Methods The drug susceptibility test was carried out by using automatic microbiological analyzer. WHONET software was used to analyze and analyze the clinical data of Acinetobacter baumannii. Results A total of 1237 strains of Acinetobacter baumannii were isolated. The highest detection rates were sputum samples. The pathogens were mainly from respiratory intensive care unit and respiratory department, followed by ICU. Susceptibility results showed Acinetobacter baumannii polymyxin B and minocycline drug resistance rate is low, in addition to other antibiotic resistance rates are high. The resistance rate of the bacteria to imipenem and meropenem was 83% -87%, and to cephalosporins, aminoglycosides and fluoroquinolones were 68.5% -92.7%. The rates of resistance to cefotaxime and ceftriaxone Resistance rate of 100%. Conclusion Acinetobacter baumannii infection in the hospital mainly concentrated in intensive care and respiratory department, the bacteria commonly used in clinical antimicrobial drugs have been generally resistant, should be strengthened Acinetobacter baumannii drug resistance monitoring and antimicrobial management.