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新生儿缺氧缺血性脑病(以下简称HIE)的发病机理,涉及面很广,近年来认识到氧自由基、兴奋性氨基酸和细胞内游离钙(以下简称Ca~(2+)i)在HIE发病中占有重要地位,三者的中心环节是细胞内钙平衡的紊乱.人体大多数细胞,其细胞内Ca~(2+)i含量极少,如我院采用Quin-2法测定正常新生儿的血单个核细胞内Ca~(2+)i浓度为116.6±28nmol/L.正常情况下,细胞膜内外存在着近10000倍的钙离子梯度差,主要依靠细胞膜对Ca~(2+)i的自然低通透性即通过钙通道以及胞膜上的Ca~(2+)-Mg~(2+)ATP酶即钙泵等的作用来维持,细胞内Ca~(2+)i的含量虽然很少,但却是发挥调节细胞机能活动的重要部分,它和环核苷酸如CAMP一样,被称为第二信使和细胞功能调节者,参与机体许多生理过程,但当细胞内钙超负荷时,却给细胞带来损害,甚至引起细胞死亡.
The pathogenesis of neonatal hypoxic-ischemic encephalopathy (hereinafter referred to as HIE), involving a wide range in recent years to recognize that oxygen free radicals, excitatory amino acids and intracellular free calcium (hereinafter referred to as Ca ~ (2) i) HIE plays an important role in the pathogenesis, the central part of the three is the intracellular calcium balance disorder.Most of the human body cells, its intracellular Ca ~ (2) i content is very small, such as our hospital using Quin-2 method to determine the normal newborn The concentration of Ca 2+ in blood mononuclear cells of children was 116.6 ± 28nmol / L. Under normal conditions, there was a nearly 10000-fold difference in calcium ion concentration inside and outside the cell membrane, mainly depending on the cell membrane Ca 2+ Of natural low permeability through the calcium channel and the membrane Ca ~ (2 +) - Mg ~ (2+) ATPase that is to maintain the role of calcium pump, intracellular Ca ~ (2) i content Although rare, but it is an important part of the regulation of cell function, which, like cyclic nucleotides such as CAMP, is called the second messenger and cell function regulator, involved in many physiological processes in the body, but when the intracellular calcium When the load, but to bring damage to cells, and even cause cell death.