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目的分析脂联素(APN)与超敏C-反应蛋白(hs-CRP)在不同类型冠心病患者中的血清水平及其临床应用价值。方法经冠状动脉造影确诊的冠心病患者92例分为稳定型心绞痛(SAP组)29例,不稳定型心绞痛(UAP组)32例,急性心肌梗死(AMI组)31例,正常健康对照组(N组)33例。采用透射免疫比浊法,分别测定各组血清中的hs-CRP浓度。结果冠心病患者血清APN水平AMI组最低,低于SAP组、UAP组及N组,差异有显著性(P<0.01),UAP组ANP水平较SAP组与N组低,差异有显著性(P<0.01),SAP组和N组间比较差异无显著性(P>0.05);血清hs-CRP水平AMI组高于SAP组、UAP组及N组(P<0.01);UAP组又高于SAP组及N组(P<0.01);SAP组和N组间比较差异无显著性(P>0.05)。结论hs-CRP水平的增高与冠心病的发生、发展显著相关。血清hs-CRP是一项预测和评价冠心病患者的重要指标,具有重要的临床价值。
Objective To analyze the serum levels of adiponectin (APN) and high sensitive C-reactive protein (hs-CRP) in patients with different types of coronary heart disease and its clinical value. Methods Ninety-two patients with coronary heart disease diagnosed by coronary angiography were divided into stable angina (SAP) group (n = 29), unstable angina pectoris group (UAP group), 31 cases of acute myocardial infarction (AMI group), normal healthy control group N group) 33 cases. Transmission electron microscopy was used to determine the concentration of hs-CRP in serum of each group. Results Serum APN levels in patients with coronary heart disease were the lowest in AMI group, but lower than those in SAP group, UAP group and N group (P <0.01). The ANP level in UAP group was lower than that in SAP group and N group (P <0.01). There was no significant difference between SAP group and N group (P> 0.05). The level of serum hs-CRP in AMI group was higher than that in SAP group, UAP group and N group Group and N group (P <0.01). There was no significant difference between SAP group and N group (P> 0.05). Conclusion The increase of hs-CRP level is significantly correlated with the occurrence and development of coronary heart disease. Serum hs-CRP is a predictor and evaluation of coronary heart disease in patients with an important indicator of important clinical value.