化疗是目前治疗恶性肿瘤的主要手段之一,但即使采用相同的化疗方案,不同人群、不同个体的化疗效果和毒性反应也不一样。常规的化疗方案,对部分患者可能敏感,治疗效果好,个别患者则可能根本无效,且常规剂量就可能出现严重的胃肠道反应、肝肾损害、骨髓抑制等。目前研究结果显示,肿瘤在发生、发展的不同时期涉及不同基因的不同变化形式,都与肿瘤治疗的敏感性密切相关。同时,调节药物代谢与转运、细胞靶点、信号途径以及细胞反应途径的基因遗传多态性对 Chemotherapy is one of the main ways to treat malignant tumors at present. However, the chemotherapeutic effects and toxicity responses vary with different populations and individuals even with the same chemotherapy regimen. Conventional chemotherapy regimens, may be sensitive to some patients, the treatment effect is good, individual patients may be completely ineffective, and the conventional dose may be serious gastrointestinal reactions, liver and kidney damage, bone marrow suppression. The current results show that different stages of the development and development of tumors involved in different forms of different genes, are closely related with the sensitivity of cancer treatment. At the same time, genetic polymorphisms that regulate drug metabolism and transport, cellular targets, signaling pathways, and cellular response pathways