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过去四十年来,食管静脉曲张破裂出血的死亡率和发病率没有改变,分流手术和内科治疗的五年存活率没有区别,分流术后半数病人合并肝性脑病,第一次出血死亡率高达42%,幸存者有1/3在一年内再出血.其它外科治疗手段包括:门-体静脉断流、曲张静脉内注入硬化剂、血管内栓塞疗法及电凝止血等,疗效也不满意,为此,药物治疗便成为一个突出的研究课题.作为降低门静脉压力的药物有后叶加压素(Shaldon 1961)及SS因子(Bosch 1981年),但有
Over the past four decades, the mortality and morbidity of esophageal variceal bleeding have not changed. There is no difference in the five-year survival rates between shunt surgery and medical treatment. Half of shunt patients have hepatic encephalopathy with a mortality rate of up to 42 % Of the survivors, one third of the survivors were bleeding within a year.Other surgical treatments include: portal-venous disconnection, varicose vein injection of sclerotherapy, endovascular embolization and electrocoagulation to stop bleeding, and the results are unsatisfactory As a result, drug therapy has become a prominent research topic.As drugs that reduce portal pressure are vasopressin (Shaldon 1961) and SS (Bosch 1981), but there are