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目的研究COPD合并糖尿病患者血清基质金属蛋白酶-9(MMP-9)的变化及相关因素分析。方法选择50例COPD患者为研究对象,按是否合并糖尿病分为COPD组(25例),COPD合并糖尿病组(25例),同期体检健康的25例作为正常对照组,检测血清MMP-9,C反应蛋白,血气分析,肺功能变化。结果 COPD组,COPD合并糖尿病组血清MMP-9和CRP水平明显高于对照组,差异有统计学意义(P<0.01)。COPD合并糖尿病组血清MMP-9和CRP水平高于COPD组,差异有统计学意义(P<0.05);COPD组,COPD合并糖尿病组PaO2水平明显低于对照组,PaCO2水平明显高于对照组,差异有统计学意义(P<0.01)。COPD合并糖尿病组PaO2,水平低于COPD组,差异有统计学意义(P<0.05),而两组间PaCO2差异无统计学意义(P>0.05);COPD组,COPD合并糖尿病组肺功能水平明显低于对照组,差异有统计学意义(P<0.01)。COPD合并糖尿病组肺功能水平低于COPD组,差异有统计学意义(P<0.05)。结论 COPD合并糖尿病检测各项指标更差,病情更严重,病死率更高,应该引起足够重视。
Objective To investigate the changes of serum matrix metalloproteinase-9 (MMP-9) in COPD patients with diabetes mellitus and its related factors. Methods Fifty COPD patients were selected as study subjects. According to whether they had diabetes or not, they were divided into COPD group (25 cases), COPD group (25 cases) and healthy group (25 cases) as normal control group. Serum MMP-9, Reactive protein, blood gas analysis, changes in lung function. Results The serum levels of MMP-9 and CRP in COPD group and COPD with diabetes mellitus group were significantly higher than those in control group (P <0.01). The levels of serum MMP-9 and CRP in COPD patients with diabetes mellitus were significantly higher than those in COPD patients (P <0.05). PaO2 levels in COPD group and COPD with diabetes mellitus group were significantly lower than those in control group, PaCO2 level was significantly higher than that in control group, The difference was statistically significant (P <0.01). The PaO2 in COPD patients with diabetes mellitus was significantly lower than that in COPD patients (P <0.05), while there was no significant difference in PaCO2 between the two groups (P> 0.05). The pulmonary function of COPD patients and COPD patients with diabetes mellitus was significantly higher Lower than the control group, the difference was statistically significant (P <0.01). The lung function of COPD patients with diabetes mellitus was lower than that of COPD patients (P <0.05). Conclusion All the indexes of COPD with diabetes mellitus are worse, the condition is more serious and the mortality rate is higher, which should be paid enough attention.