静脉曲张出血是肝硬化的常见和严重并发症,可使大约1/3的病人致死,70%的生存者在1年内将再次出血,这些病人需得到治疗以减少静脉曲张出血复发的危险性,用心得安(pro-pranolol)有可能达到目的.为了解门脉压力的降低较少是否与静脉曲张出血的高危险性相关,作者研究了药物治疗所产生的血流动力学 Bleeding from varicose veins is a common and serious complication of cirrhosis that can kill about a third of patients and 70% of survivors will bleed again within a year. These patients need treatment to reduce the risk of recurrence of variceal bleeding, The goal of pro-pranolol may be achieved.To find out whether reduced portal pressure is less associated with high risk of variceal hemorrhage, the authors studied the pharmacokinetics of hemodynamics