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0引言间质干细胞(mesenchymal stem cells,MSCs)是来源于中胚层具有高度自我更新能力和多向分化潜能的干细胞,具有极好的迁移能力和肿瘤趋向性,在肿瘤生长的微环境中,肿瘤细胞及其周围的纤维基质分泌各种细胞因子可促进MSCs向肿瘤部位迁移集聚并增殖分化参与肿瘤微环境中基质的
0 Introduction Mesenchymal stem cells (MSCs) are stem cells derived from mesoderm with high self-renewal ability and multi-directional differentiation potential. They have excellent migration ability and tumor tendency. In the microenvironment of tumor growth, Secretion of various cytokines by the cells and their surrounding fibrous matrices can promote the migration and accumulation of MSCs to the tumor site and proliferate and differentiate into the stroma of the tumor microenvironment