肝硬化失代偿出现肝性脑病并可逆性皮质盲临床罕见,国内报道极少,本文收集近年来6例和我院2例,其中1例并皮质聋,共8例,均为男性,年龄35～62岁。简述分析。一、病因:8例中有7例为肝炎后肝硬化,1例为Budd-Chiari综合征并肝硬化。肝硬化为基本病因。本组乙型肝炎病毒标志物示:HBsAg(+)、抗-HBO(+)、HBeAg(+),肝功能异常。B超:肝硬化、脾大、腹水征。肝性脑病表现并双目失明,1例并失听。有记载血清白蛋白<30g/L5例,甲胎球蛋白阴性3例,血氨升高1例及正常1例。二、发病机理:本组以肝炎后肝硬化为主,肝脏基本病理为肝硬化。肝性脑病并皮质盲的发病机理目前尚不清楚,可能为:1.肝性脑病氨中毒有关,血氨升高引起脑细胞代谢紊乱和一系列中枢神经的活动 Liver cirrhosis decompensation of hepatic encephalopathy and reversible cortical blind clinical rare, very few domestic reports, this collection of 6 cases in recent years and our hospital in 2 cases, 1 case of cortical deafness, a total of 8 cases were male, age 35 ~ 62 years old. Brief analysis. First, the etiology: 7 of 8 cases of posthepatitis cirrhosis, 1 case of Budd-Chiari syndrome and cirrhosis. Cirrhosis is the basic cause. The group of hepatitis B virus markers showed: HBsAg (+), anti-HBO (+), HBeAg (+), liver dysfunction. B super: cirrhosis, splenomegaly, ascites sign. Hepatic encephalopathy performance and blindness, 1 case and missed. There are records of serum albumin <30g / L 5 cases, 3 fetuin negative, elevated blood ammonia in 1 case and normal in 1 case. Second, the pathogenesis: This group mainly in post-hepatitis cirrhosis, liver cirrhosis of the basic pathology. The pathogenesis of hepatic encephalopathy and cortical blindness is not yet clear, may be: 1. Hepatic encephalopathy ammonia poisoning, elevated blood ammonia causes brain cell metabolic disorders and a series of activities of the central nervous system