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本文报告在20个具有不同梯度钩虫感染率的村,用噻嘧啶加左旋眯唑的化疗方法,作实现阻断钩虫传播阈值的方案研究。结果发现,居民感染率在10％以下的村,可以用1次普查普治加1～2次复查复治达到阈值;感染率在10～40％的村可以在一个非感染季节内进行2次普查普治加1～2次复查复治或在连续两个冬春各进行1次普查普治加1～2次复查复治以实现阈值;感染率在40～50％的村,可以在一个非感染季节进行2次普查普治加1～2次复查、复治再加非阳性者1次顿服噻嘧啶或在连续三个冬春各进行1次普查普治加1～2次复查、复治以实现阈值。感染率在50％以上的村,经连续3年各进行1次普查普治(其中80％以上的村作1次全民服药)加复查复治1～3次,虽居民感染率和感染度有显著下降,但仍未能达到阈值。
In this paper, we reported the use of pyrimethamine plus levamisole in 20 villages with different rates of hookworm infection to develop a protocol for blocking the threshold of hookworm transmission. The results showed that villages with infection rates below 10% could reach the threshold with 1 census plus 1 ~ 2 re-treatment and re-treatment. The villages with infection rates of 10-40% could be treated twice in a non-infected season Census Pichia 1 or 2 times for retreatment retreatment Or for two consecutive winter and spring for 1 census Pugi plus 1 or 2 times for retreatment in order to achieve the threshold; infection rate of 40 to 50% of the village, in a Non-infected season, 2 times the general survey plus 1 to 2 times the review, re-treatment plus non-positive one dose of pyrimethamine or in the winter and spring for each of a general survey plus 1 to 2 times the review, Retreatment to achieve the threshold. The infection rate of more than 50% of villages, for three consecutive years each conducted a general survey (including more than 80% of the village for a universal medication) plus review of rehabilitation 1 to 3 times, although the rate of infection and infection Significant decline, but still failed to reach the threshold.