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目的探讨过氧化物酶体增殖物激活受体γ辅激活因子1α(PGC-1α)与乳腺癌发生及发展的相关性。方法乳腺癌患者和同期非乳腺癌患者各86例,采用免疫组化检测组织中PGC-1α蛋白表达水平,分析PGC-1仅与乳腺癌发生的相关性,针对乳腺癌患者不同病理分期、淋巴结转移情况分组,观察PCC-1α与乳腺癌发生、发展的关系。结果乳腺癌患者PGC-1α表达水平高于非乳腺癌患者,Ⅲ、Ⅳ期乳腺癌PGC-1α表达水平高于Ⅰ、Ⅱ期乳腺癌患者,淋巴结转移阳性组PGC-1α的表达水平高于淋巴结转移阴性组,差异均有统计学意义(P<0.05)。采用Logistic回归分析PGC-1α与乳腺癌发生、病理分期、淋巴结转移的相关性,差异均有统计学意义(P<0.05),且各项指标最大似然估计值和OR值均>0。结论 PGC-1α表达水平与乳腺癌的发生、病理分期、淋巴结转移呈正相关,有可能作为乳腺癌诊断和判断预后的指标。
Objective To investigate the correlation between peroxisome proliferator - activated receptor γ coactivator 1α (PGC - 1α) and the occurrence and development of breast cancer. Methods The expression of PGC-1α protein in breast cancer patients and non-breast cancer patients were detected by immunohistochemistry. The correlation between PGC-1 and breast cancer was analyzed. The expression of PGC- Metastasis group, observe the relationship between PCC-1α and occurrence and development of breast cancer. Results The expression level of PGC-1α in breast cancer patients was higher than that in non-breast cancer patients. The expression level of PGC-1α in stage Ⅲ and Ⅳ breast cancer was higher than that in stage Ⅰ and Ⅱ breast cancer. The expression level of PGC-1α in lymph node positive group was higher than that in lymph node Metastasis negative group, the difference was statistically significant (P <0.05). Logistic regression analysis showed that the correlation between PGC-1α and the occurrence of breast cancer, pathological stage and lymph node metastasis were statistically significant (P <0.05), and the maximum likelihood of each index and OR values were> 0. Conclusion The expression level of PGC-1α is positively correlated with the occurrence of breast cancer, pathological stage and lymph node metastasis, which may be used as an index for the diagnosis and prognosis of breast cancer.