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目的合成薯蓣皂苷类似物并初步研究其抗肿瘤活性。方法采用直接苷化法合成薯蓣皂苷类似物,并用MTT法筛选其体外抗癌活性。结果用简单高效的方法合成了化合物,并通过1HNMR、13CNMR、ESI-Q-TOF-MS和单晶衍射证实其结构。结论通过MTT法发现化合物Ⅴ和Ⅶ对乳腺癌细胞MDA-MB 231有一定的抑制作用。
Objective To synthesize diosgenin analogues and study their anti-tumor activity. Methods Direct digestible method was used to synthesize diosgenin analogs. The antitumor activity in vitro was screened by MTT method. Results The compounds were synthesized in a simple and efficient way and their structures were confirmed by 1HNMR, 13CNMR, ESI-Q-TOF-MS and single crystal diffraction. Conclusion MTT assay showed that compounds Ⅴ and Ⅶ inhibited breast cancer cell MDA-MB 231 to some extent.