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目的 探讨肺炎支原体感染时外周血嗜酸细胞计数变化及血清总IgE水平 ,以阐明肺炎支原体感染与支气管哮喘发病的关系。方法 对临床病人采用回顾性分析 ,肺炎支原体感染患儿 2 0例 (包括肺炎及支气管炎 ) ;支气管哮喘患儿 30例 ;正常对照组 2 5例。抗凝静脉血、伊红染色、光学显微镜下计数 ;ELISA方法检测血清总IgE。结果 肺炎支原体感染组外周血嗜酸细胞计数和血清总IgE水平均高于正常对照组 (P <0 0 5 ) ,而低于支气管哮喘组 (P <0 0 1)。结论 肺炎支原体感染引起的外周血嗜酸细胞计数及血清总IgE水平增高 ,在持续性咳嗽和支气管哮喘发病中起着重要作用
Objective To investigate changes of peripheral blood eosinophil count and serum total IgE levels in patients with Mycoplasma pneumoniae infection in order to clarify the relationship between Mycoplasma pneumoniae infection and the pathogenesis of bronchial asthma. Methods A retrospective analysis of clinical patients, 20 cases of children with Mycoplasma pneumoniae infection (including pneumonia and bronchitis); 30 cases of bronchial asthma in children; normal control group 25 cases. Anticoagulation venous blood, Eosin staining, counting under light microscope; ELISA method for total serum IgE. Results The levels of eosinophils and serum total IgE in patients with Mycoplasma pneumoniae infection were higher than those in the control group (P <0.05), but lower than those in the bronchial asthma group (P <0.01). Conclusion Mycoplasma pneumoniae infection caused by peripheral blood eosinophil count and serum total IgE levels increased in the pathogenesis of persistent cough and bronchial asthma play an important role