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观察两种药物对高脂血症和心肌缺血模型的影响,对两者的药效进行比较。结果表明:德欧心捷宁(200mg/kg)预防组、治疗组、地奥心血康(200mg/kg)预防组、治疗组均能不同程度地降低高脂血症大鼠的TC、TG水平,有升高大鼠HDL—C水平的趋势,但对LDL—C水平均无明显作用。对垂体后叶素、盐酸异丙肾上腺素所致大鼠心肌缺血均有一定的对抗作用,表现在对大鼠心率、T波和S—T段改变三方面均有不同程度的对抗作用。比较而言,德欧心捷宁的降脂作用略优于地奥心血康,地奥心血康的抗心肌缺血作用稍强。
Observe the effects of two drugs on hyperlipidemia and myocardial ischemia models, and compare the efficacy of the two drugs. The results showed that: Deoxin Xinjiening (200mg/kg) prevention group, treatment group, Dioxinxuekang (200mg/kg) prevention group, treatment group can reduce the level of TC, TG in hyperlipidemic rats to varying degrees, there is an increase in rats The trend of HDL-C levels, but no significant effect on LDL-C levels. It has a certain antagonistic effect on rat myocardial ischemia induced by pituitrin and isoprenaline hydrochloride. It shows that there are different degrees of antagonistic effects on rat heart rate, T-wave and S-T segment changes. In comparison, the lipid-lowering effect of DEO Xin Jie Ning is slightly better than that of Dio-Xue Xue Kang, and the anti-myocardial ischemia effect of Di Ao Xin Xue Kang is slightly stronger.