本文总结了HFRS病毒鸡胚组织培养灭活疫苗的研制和效果观察。证明其免疫原性好,安全可靠。为生产出血热灭活疫苗提供了成功的经验。在小量人体免疫时,第1针血清阳转率为4/5,第2针阳转率5/5。几何平均滴度显著高于第1针,为1:33—1:160。扩大人群免疫效果更进一步证明HFRS抗体阳转率颇理想,于第2针免疫后21天取血检查抗HFRS抗体阳性检出率为百分之百。 This article summarizes the HFRS virus chick embryo tissue culture inactivated vaccine development and observation. Proved its good immunogenicity, safe and reliable. It provides a successful experience in producing the vaccine of hemorrhagic fever inactivated. In a small amount of human immunity, the first needle seroconversion rate of 4/5, the second needle positive rate of 5/5. The geometric mean titer was significantly higher than that of the first one, which was 1: 33-1: 160. Expanded population immune effect further evidence of positive rate of HFRS antibody positive, in the first 2 days after immunization 21 blood tests to detect anti-HFRS antibody positive detection rate was 100%.