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目的探讨尿核基质蛋白22(NMP22)与膀胱移行细胞癌病理分级分期的关系。方法对1999年6月至2005年3月间就诊的642例膀胱癌患者行尿液NMP22检测,检测后1周~1个月内行膀胱镜和病理学检查,按病理分级分为3组,G1组为69例(男58例、女11例),G2组为375例(男255例、女120例),G3组为198例(男143例、女55例),比较中位数NMP22浓度。同时,对其中239例患者按病理分期分为3组,PT1组为121例(男76例、女45例),PT2组为65例(男37例、女28例),PT3组为53例(男36例、女17例),比较中位数NMP22浓度。结果G1、G2和G3组之间中位数NMP22浓度比较,差异有统计学意义(χ2=67·547,P<0·001);PT1、PT2和PT3组之间中位数NMP22浓度比较,差异有统计学意义(χ2=20·629,P<0·001)。结论尿NMP22浓度与膀胱移行细胞癌的病理分级、分期有相关关系。
Objective To investigate the relationship between urinary nuclear matrix protein 22 (NMP22) and pathological grading and staging of bladder transitional cell carcinoma. Methods Urine NMP22 was detected in 642 patients with bladder cancer from June 1999 to March 2005. Cystoscopy and pathology were performed within 1 week to 1 month after the test. The pathological grades were divided into 3 groups: G1 There were 69 cases (58 males and 11 females), 375 cases (255 males and 120 females) in G2 group and 198 cases (143 males and 55 females) in G3 group. The median NMP22 concentration . At the same time, 239 patients were divided into three groups according to the pathological stage. There were 121 cases (76 males and 45 females) in PT1 group, 65 cases (37 males and 28 females) in PT2 group and 53 cases in PT3 group (36 males and 17 females). The median NMP22 concentrations were compared. Results The median concentration of NMP22 in G1, G2 and G3 groups was significantly different (χ2 = 67.547, P <0.001). Compared with the median NMP22 concentrations in PT1, PT2 and PT3 groups, The difference was statistically significant (χ2 = 20.629, P <0.001). Conclusion Urinary NMP22 concentration and bladder transitional cell carcinoma pathological grading, staging have a correlation.