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目的:研究阿托伐他汀对改善骨髓间充质干细胞以治疗急性心肌梗死的治疗情况。方法:选取42例在2007年1月~2012年12月来我院接受骨髓间充质干细胞治疗的急性心肌梗死病患进行研究,将其进行随机均分为3组,每一组为14例病患,他们分别为对照组,观察组1、观察组2。对照组为AMI常规治疗组,观察组1为只使用阿托伐他汀进行治疗,观察组2为使用阿托伐他汀治疗的同时使用MSCs移植。结果:对照组、观察组1、观察组2均无死亡病例,病患获得康复。各组小组间治疗前后的血脂指标变化比较无统计学意义,P>0.05。同位素心肌代谢显像评价存活心肌方面,观察组2明显优于观察组1和对照组。结论:使用阿托伐他汀改善骨髓间充质干细胞治疗急性心肌梗死是有效的,联合MSCs移植后,发现其治疗的效果与传统治疗方法相比更加理想,值得在临床上进行推广。
Objective: To study the therapeutic effect of atorvastatin on the improvement of bone marrow mesenchymal stem cells for the treatment of acute myocardial infarction. Methods: Forty-two patients with acute myocardial infarction who received bone marrow mesenchymal stem cells from January 2007 to December 2012 in our hospital were randomly divided into three groups, each group was 14 Patients, they were control group, observation group 1, observation group 2. The control group was AMI conventional treatment group, observation group 1 was treated with atorvastatin only, and observation group 2 was treated with atorvastatin combined with MSCs transplantation. Results: In the control group, observation group 1 and observation group 2, no deaths were found and the patients recovered. There was no significant difference in the changes of blood lipid between the groups before and after treatment (P> 0.05). Isotopic myocardial metabolic imaging evaluation of viable myocardium, observation group 2 was significantly better than the observation group 1 and control group. CONCLUSION: Atorvastatin is effective in improving AMI in acute myocardial infarction. Combined with MSCs transplantation, its therapeutic effect is more ideal than conventional treatment, which is worth to be popularized clinically.