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吐鲁番夏季炎热干旱,居民饮水量很大,致摄氟量增加引起氟中毒流行。本文对该区两个水氟含量不同的生产队维吾尔族农民血清LPO、-SH和尿Hyp/Cr值进行了测定分析。结果显示:两队农民血清-SH含量虽有差别,但无显著性差异(P>0.05)。水氟含量(0.91mg/L)较高的A队农民血清LPO和尿Hyp/Cr值均高于水氟含量(0.58mg/L)低的B队农民,差别均有显著性。LPO含量分别为:3.47±0.75nmol/ml和2.99±0.69nmol/ml(P<0.05);尿Hyp/Cr值分别为:29.20±9.98mg/g和22.29±7.52mg/g(P<0.01)。表明脂质过氧化和胶原分解代谢受水氟的影响。提示血清LPO和尿HYP/Cr值可作为氟中毒的辅助诊断指标。
Turpan summer hot and dry, residents drinking water is very large, increased fluorine exposure caused fluorosis epidemic. In this paper, we measured the serum LPO, -SH and urinary Hyp / Cr in two Uyghur farmers with different fluoride content in the area. The results showed that there was no significant difference between the two groups of peasant serum-SH content (P> 0.05). The LPO and urinary Hyp / Cr values of peasant A team with higher water fluoride (0.91 mg / L) were higher than those of peasant B team with low water fluoride (0.58 mg / L), the differences were significant. LPO contents were 3.47 ± 0.75nmol / ml and 2.99 ± 0.69nmol / ml respectively (P <0.05). The urine Hyp / Cr values were 29.20 ± 9.98mg / g and 22.29 ± 7.52mg / g respectively . This indicates that lipid peroxidation and collagen catabolism are affected by water fluoride. Tip serum LPO and urine HYP / Cr value can be used as an auxiliary diagnosis of fluoride poisoning.