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应用日立８３５－５０型氨基酸自动分析仪，对３０例发病１２小时至３天急性脑梗塞患者的血清氨基酸和其中１４例患者的脑脊液氨基酸水平进行检测，并与对照组进行比较。结果显示，患者组血清及脑脊液中兴奋性氨基酸递质谷氨酸（Ｇｌｕ）和天门冬氨酸（Ａｓｐ）水平明显升高；牛黄酸（Ｔａｕ）、甘氨酸（Ｇｌｙ）递质水平下降，但差异不显著。血清中Ｇｌｕ和Ａｓｐ水平变化与脑梗塞直径呈显著正相关，与神经功能评分呈正相关。提示Ｇｌｕ和Ａｓｐ参与脑梗塞的病理过程，血清Ｇｌｕ和Ａｓｐ水平可作为临床观察其病情严重程度、梗塞面积的客观指标。
Amino acid analyzer of Hitachi 835-50 automatic analyzer was used to detect the serum amino acids in 30 patients with acute cerebral infarction from 12 hours to 3 days and 14 cases of patients with cerebrospinal fluid amino acid levels were compared with the control group. The results showed that the levels of glutamate (Glu) and aspartate (Asp) in serum and cerebrospinal fluid of patients were significantly increased; the levels of Tau and Gly decreased, but the difference Not obvious. Serum Glu and Asp levels and cerebral infarction diameter was significantly positively correlated with neurological function score was positively correlated. Suggesting that Glu and Asp participate in the pathological process of cerebral infarction, serum Glu and Asp levels can be used as clinical indicators of the severity of the disease, infarct size.