骨髓增生异常综合征(MDS)是造血干细胞获得性克隆性异常疾病,以无效造血及外周血细胞进行性减少为特征,粒细胞缺乏致感染及血小板减少致出血是最常见的死亡原因,10%～40%患者可能发展为急性髓细胞白血病(AML)。小剂量细胞生长抑制剂、细胞生长因子及其它分化诱导剂可延长 MDS 患者生存期、改善部分患者的生 Myelodysplastic syndrome (MDS) is an acquired clonal abnormality of hematopoietic stem cells characterized by ineffective hematopoiesis and progressive reduction of peripheral blood cells. Hemorrhage caused by agranulocytosis and thrombocytopenia is the most common cause of death. 10% Forty percent of patients may develop acute myeloid leukemia (AML). Small doses of cytostatics, cytokines and other differentiation-inducing agents can prolong the survival of patients with MDS and improve the health of some patients