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目的研究川崎病(KD)患儿血清可溶性血管内皮生长因子(sVEGF)和生长转化因子β1(TGF-β1)与冠状动脉直径的关系,探讨其参与冠状动脉损伤的机制。方法研究对象为2007年1月至2009年1月期间在山东大学齐鲁儿童医院住院治疗、发生冠状动脉扩张的KD急性期患儿30例。使用双抗体夹心酶联免疫吸附法(ELISA),测定KD患儿sVEGF和TGF-β1,并与冠状动脉的直径进行相关性分析。结果 KD患儿急性期sVEGF和TGF-β1明显高于恢复期,且在急性期,此两项指标与冠状动脉直径呈正相关。结论 sVEGF和TGF-β1在KD冠状动脉损伤形成中发挥重要的生理病理作用,其机制可能与其促进血管内皮的损伤有关。
Objective To investigate the relationship between serum soluble vascular endothelial growth factor (sVEGF) and transforming growth factor-β1 (TGF-β1) and coronary artery diameter in children with Kawasaki disease (KD) and to explore the mechanism of its involvement in coronary artery injury. Methods The subjects were hospitalized in Qilu Children’s Hospital of Shandong University from January 2007 to January 2009, and 30 children with acute KD undergoing coronary artery dilation were enrolled. Double antibody sandwich enzyme-linked immunosorbent assay (ELISA) was used to determine sVEGF and TGF-β1 in children with KD and their correlation with coronary diameter was analyzed. Results The acute phase sVEGF and TGF-β1 in children with KD were significantly higher than those in recovery stage. In the acute phase, the two indexes were positively correlated with the diameter of coronary artery. Conclusion sVEGF and TGF-β1 play an important physiological and pathological role in the formation of KD coronary artery injury, and its mechanism may be related to its promotion of vascular endothelial injury.