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从1983年11月～1989年8月,采用以顺铂、平阳霉素为主,分别与Etoposide(v_p-16)、VCR、MMC、Nitrocaphane(AT-1258)结合的DEP、DVP、DMP、DNP4种联合化疗方案,随机分组治疗晚期食管癌166例,完全缓解(CR)14例(8.4％),部分缓解(PR)71例(42.8％),稍效(MR)43例(25.9％),无效(NR)38例(22.9％),有效率(CR+PR)51.2％(85/166)。化疗方案DEP(45.4％)和DVP(46.2％)缓解率相似,DMP(56.1％)和DNP(57.5％)较高.但无统计学差异(P>0.05)。缓解期2～4月。中位生存期7月。有消化道反应者148例,恶心(Ⅰ度)91例,呕吐44例(Ⅱ度38例,Ⅲ度6例)。白细胞低于4×10~9/L者45例(Ⅰ度40例,Ⅱ度5例).血小板低于80×10~9/L者27例(Ⅰ度)。3例有轻度肾功能损伤。33例有发热反应。
From November 1983 to August 1989, DEP, DVP, DMP, and DNP4 that were mainly combined with cisplatin and pingyangmycin, respectively, were combined with Etoposide (v_p-16), VCR, MMC, and Nitrocaphane (AT-1258). In a combined chemotherapy regimen, 166 patients with advanced esophageal cancer were randomly divided into groups. Complete remission (CR) was 14 (8.4%), partial remission (PR) was 71 (42.8%), and slightly effective (MR) was 43 (25.9%). Ineffective (NR) 38 cases (22.9%), effective (CR+PR) 51.2% (85/166). The response rates of DEP (45.4%) and DVP (46.2%) were similar in chemotherapy regimens, and DMP (56.1%) and DNP (57.5%) were higher, but there was no statistical difference (P>0.05). Remission period 2 April. The median survival period is July. There were 148 patients with gastrointestinal reactions, 91 patients with nausea (degree I), and 44 patients with vomiting (38 patients with II degree and 6 patients with III degree). There were 45 patients with leukocytes less than 4×10-9/L (40 patients in degree I and 5 patients in degree II). The platelet counts were lower than 80×10-9/L in 27 patients (degree I). Three patients had mild renal impairment. 33 cases had a fever reaction.