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为探讨长时间低剂量接触四氯乙烯对人体的危害,我们进行了该项实验研究。实验分组为1356 mg/kg、678 mg/kg、339mg/kg三个剂量组和阳性、阴性对照组共5组。染毒组对雌性昆明种小鼠进行灌胃染毒,染毒五分娩停止。染毒组现察其对仔代的行为功能改变,并对仔鼠的中枢神经系统做了病理学检查,结果现察到:1.雌鼠染毒各剂量组体格发育未见改变,即仔鼠行为功能发生异常并呈剂量相关性,表明行为改变是发育进程中,神经系统受损较为敏感的指标。2.电镜超微结构显示仔鼠中枢神经系统(大脑皮层运动区、小脑皮层)的中毒损伤是动物行为异常病理基础。
To investigate the long-term low-dose exposure to tetrachlorethylene on the human body, we conducted the experimental study. The experimental groups were 1356 mg / kg, 678 mg / kg, 339 mg / kg three dose groups and positive, negative control group of 5 groups. Toxicity group of female Kunming mice gavage, exposure to five childbirth stopped. In the exposure group, we observed the changes of behavioral function of the offspring, and did the pathological examination on the central nervous system of the offspring. The results showed: 1. There was no change in the physical development of each dose group Rat behavioral abnormalities and dose-related abnormalities, indicating that behavioral changes in the development process, the nervous system damage is more sensitive indicators. 2. Electron microscopy showed that the poisoning of the central nervous system (cortex motor area, cerebellar cortex) of offspring rats is the basis of abnormal behavior of animals.